高齡父親 易生自閉症孩子
<P style="LINE-HEIGHT: 150%; MARGIN: 0cm 20pt 0pt 0cm; WORD-BREAK: break-all" class=MsoNormal><SPAN style="LINE-HEIGHT: 150%; FONT-FAMILY: '新細明體','serif'; COLOR: dimgray; FONT-SIZE: 10pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">【世界日報</SPAN><SPAN style="LINE-HEIGHT: 150%; FONT-FAMILY: 細明體; COLOR: dimgray; FONT-SIZE: 10pt; mso-bidi-font-family: 細明體; mso-font-kerning: 0pt" lang=EN-US>╱</SPAN><SPAN style="LINE-HEIGHT: 150%; FONT-FAMILY: '新細明體','serif'; COLOR: dimgray; FONT-SIZE: 10pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">編譯中心綜合</SPAN><SPAN style="LINE-HEIGHT: 150%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: dimgray; FONT-SIZE: 10pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>4</SPAN><SPAN style="LINE-HEIGHT: 150%; FONT-FAMILY: '新細明體','serif'; COLOR: dimgray; FONT-SIZE: 10pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">日電】</SPAN><SPAN style="LINE-HEIGHT: 150%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: dimgray; FONT-SIZE: 10pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>2012.04.06 09:56 am<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">兒童患自閉症的原因至今未明，研究人員</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>4</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">日說，又發現三個與自閉症有關的基因突變，而且有一些證據顯示高齡父母，特別是父親年齡大的孩子比較容易得自閉症。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">「自然」期刊發表三篇研究報告指出，泛自閉症障礙症候群</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>(ASD)</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">的患者，體內的</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>CHD8</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">、</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>SNC2A</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">和</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>KATNAL2</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">三種基因都有突變現象。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">這些研究都把數百名</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>ASD</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">患者的基因，與正常人的基因圖譜加以比較。不過，研究人員說，還有很多有關的問題基因仍待發掘，而要瞭解這些基因如何擾亂正常的生理機能，構成更艱難的挑戰。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">紐約西奈山醫學院神經學教授巴克斯邦</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>(Joseph Buxbaum)</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">說：「我們現在知道自閉症涉及很多基因，現已發現的只有大約</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>10%</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">。」</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>ASD</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">涵蓋讓人無法或不願與別人溝通或互動的廣泛性格障礙，一些患者的認知能力發展遲緩，還有些人在數學或音樂等特定領域表現驚人的天賦。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">以前的研究發現</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>ASD</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">與基因有強烈關係，有些家族更接連出現這種病例，可是專家對這種關聯缺乏瞭解。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">耶魯大學研究團隊對這種偶發性自閉症現象進行研究，並表示他們相信新的基因突變約有</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>15%</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">發生在受孕之時。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">高齡父親比較容易生下自閉兒，而這點部分說明了為什麼高齡父母的孩子得自閉症的風險較高。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">但是，這些突變如何影響腦部發育還不清楚。另一項探討偶發性自閉症的研究則發現，許多新的基因變異似乎與自閉症本身無關。</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>
<P style="LINE-HEIGHT: 190%; MARGIN: 0cm 0cm 0pt; WORD-BREAK: break-all; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" class=MsoNormal><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">巴克斯邦說：「我們必須研究更多父母和他們的自閉兒，以發現這些基因對</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US>ASD</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: '新細明體','serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">的重要性。一旦瞭解這些基因的特性，將能導致提早診斷和發展新的藥物。這對促進自閉症的治療非常重要。」</SPAN><SPAN style="LINE-HEIGHT: 190%; FONT-FAMILY: 'Arial','sans-serif'; COLOR: #414141; FONT-SIZE: 11.5pt; mso-font-kerning: 0pt; mso-fareast-font-family: 新細明體" lang=EN-US> <o:p></o:p></SPAN></P>