幹細胞治療 糖尿病患可望免截肢
<p style="margin: 0cm 0cm 0pt;" class="MsoNormal"><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">【聯合報</span><span style="FONT-FAMILY: 細明體; mso-bidi-font-family: 細明體">╱</span><span style="font-family: '新細明體','serif';">記者陳惠惠／台北報導】</span></font></p><p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal"><br><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin"></span><span lang="EN-US"><font face="Calibri"><o:p></o:p></font></span></font></p>
<p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">國內每年有數千名糖尿病患因足部病變，被迫截肢。台北榮總與陽明大學合作，把低氧培養的間葉幹細胞打進糖尿病鼠體內，能增加組織、血管新生能力，九成老鼠免截肢厄運。</span><font face="Calibri"> <span lang="EN-US"><o:p></o:p></span></font></font></p>
<p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">北榮教研部主任林幸榮說，未來若發展順利，末期糖尿病患被迫截肢的機率將大幅降低。研究團隊已向衛生署申請人體試驗，核准後就可針對糖尿病患進行下肢動脈血管堵塞治療，第一期臨床試驗預計招收十八人。</span><font face="Calibri"> <span lang="EN-US"><o:p></o:p></span></font></font></p>
<p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">陽明大學臨床醫學研究所教授洪士杰說，幹細胞可分為胚胎、成體幹細胞兩大類，間葉幹細胞屬於成體幹細胞，可從骨髓及多種器官分離出來。</span><font face="Calibri"> <span lang="EN-US"><o:p></o:p></span></font></font></p>
<p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">榮陽團隊研究發現，人體組織細胞怕氧氣不足，間葉幹細胞正好相反；在氧氣濃度只有百分之一到七的低氧環境下，世代培養六十天所獲得的間葉幹細胞數量，是正常氧氣濃度的一百到一千倍。低氧不只能促進細胞分裂，長得更快，而且還會長得更好，能減緩細胞老化發生。</span><font face="Calibri"> <span lang="EN-US"><o:p></o:p></span></font></font></p>
<p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">洪士杰說，未注射低氧培養間葉幹細胞的糖尿病鼠，一周後九成都須截肢，經治療，九成糖尿病鼠都能保住牠們的腿。他說，低氧下間葉幹細胞的分泌物，可以促進皮膚傷口癒合，並增加血管新生，增進糖尿病鼠骨折癒合能力。</span><font face="Calibri"> <span lang="EN-US"><o:p></o:p></span></font></font></p>
<p style="MARGIN: 0cm 0cm 0pt" class="MsoNormal"><font size="3"><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">榮陽團隊此研究成果已發表在「分子細胞（</span><span lang="EN-US"><font face="Calibri">Molecular Cell</font></span><span style="FONT-FAMILY: '新細明體','serif'; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 新細明體; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin">）」，本月十二日在網路公開。洪士杰說，除了治療周邊動脈血管堵塞，間葉幹細胞還可應用在關節軟骨損傷及退化、自體免疫疾病及克隆氏症等治療。</span><font face="Calibri"> <span lang="EN-US"><o:p></o:p></span></font></font></p>